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- Below you find a complete list of
publications from the latest till 2004.
- 2012
Deleted in colorectal carcinoma suppresses metastasis in
p53-deficient mammary tumours.
Krimpenfort P, Song JY, Proost N, Zevenhoven J, Jonkers J, Berns A.
Nature. 2012 Feb 22;482(7386):538-41. doi: 10.1038/nature10790.
- 2011
Insertional mutagenesis identifies multiple networks of cooperating
genes driving intestinal tumorigenesis.
March HN, Rust AG, Wright NA, Ten Hoeve J, de Ridder J, Eldridge M,
van der Weyden L, Berns A, Gadiot J, Uren A, Kemp R, Arends
MJ, Wessels LF, Winton DJ, Adams DJ.
Nat Genet. 2011
Nov 6. doi: 10.1038/ng.990. [Epub ahead of print]
Rapid validation of cancer genes in chimeras derived from
established genetically engineered mouse models.
Huijbers IJ, Krimpenfort P,
Berns A, Jonkers J.
Bioessays.
2011 Jul 7. doi: 10.1002/bies.201100018.
Cell of origin of small cell lung cancer: inactivation of Trp53 and
rb1 in distinct cell types of adult mouse lung.
Sutherland KD, Proost N, Brouns I, Adriaensen D, Song JY,
Berns A.
Cancer Cell. 2011 Jun
14;19(6):754-64.
Computational identification of insertional mutagenesis targets for
cancer gene discovery.
de Jong J, de Ridder J, van der Weyden L, Sun N, van Uitert M,
Berns
A, van Lohuizen M, Jonkers J, Adams DJ, Wessels LF
Nucleic Acids Res.
2011 Jun 7.
Responding to the economy: raising the profile of vaccines for
children.
Berns A, Blum A, Etkind P
J Public Health Manag Pract. 2011 Jul-Aug;17(4):390-2.
A functional role for tumor cell heterogeneity in a mouse model of
small cell lung cancer.
Calbo J, van Montfort E, Proost N,
van Drunen E, Beverloo HB, Meuwissen R, Berns A.
Cancer Cell. 2011 Feb 15;19(2):244-56.
For better or for worse: the role of Pim oncogenes in tumorigenesis.
Nawijn MC, Alendar A,
Berns A.
Nat Rev Cancer. 2011 Jan;11(1):23-34. Epub 2010 Dec 9.
Review.
- 2010
Cancer: The
blindspot of p53
Berns A.
Nature.
2010 Nov 25;468(7323):519-20. (No abstract available)
Cell of origin
of lung cancer
Sutherland KD, Berns A.
Mol
Oncol. 2010 Jun 8.
Rapid and Robust Transgenic High-Grade Glioma Mouse Models for
Therapy-Intervention Studies
de Vries NA, Bruggeman SW, Hulsman D, de Vries HI, Zevenhoven J,
Buckle T, Hamans BC, Leenders WP, Beijnen JH, van Lohuizen M, Berns
A, van Tellingen O.
Clin Cancer Res. 2010 May 14.
Drugging drug
resistance.
Dannenberg JH, Berns A
Cell.
2010 Apr 2;141(1):18-20.
Novel candidate cancer genes identified by a Large-Scale Cross-Species
comparative oncogenomics approach.
Mattison J, Kool J, Uren AG, de Ridder J, Wessels L, Jonkers J, Bignell
GR, Butler A, Rust AG, Brosch M, Wilson CH, van der Weyden L,
Largaespada DA, Stratton MR, Futreal PA, van Lohuizen M, Berns A,
Collier LS, Hubbard T, Adams DJ.
Cancer Res; 70(3); 883-95.
Insertional Mutagenesis in Mice Deficient for p15Ink4b, p16Ink4a,
p21Cip1 and p27Kip1 Reveals Cancer gene Interactions and Correlations
with Tumor Phenotypes.
Kool J, Uren AG, Martins CP, Sie D, de Ridder J, Turner G, van Uitert M,
Matentzoglu K, Lagcher W, Krimpenfort P, Gadiot J, Pritchard C, Lenz J,
Lund AH, Jonkers J, Rogers J, Adams DJ, Wessels L, Berns A, van Lohuizen
M.
Cancer Res. 2010 Jan 15;70(2):520-31
Frat oncoproteins act at the crossroad of canonical and noncanonical
Wnt-signaling pathways.
van Amerongen R, Nawijn MC, Lambooij JP, Proost N, Jonkers J,
Berns A.
Oncogene. 2010 Jan 7;29(1):93-104.
- 2009
Immune response in lung cancer mouse model mimics human anti-Hu
reactivity.
Kazarian M, Calbo J, Proost N, Carpenter CL, Berns A, Laird-Offringa IA.
J Neuroimmunol. 2009 Dec 10;217(1-2):38-45.
A high-throughput splinkerette-PCR method for the isolation and
sequencing of retroviral insertion sites.
Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH, Wilson CH, Rance
R, Jonkers J, van Lohuizen M, Berns A, Adams DJ
Nat Protoc. 2009; 4(5): 789-98.
High-throughput insertional mutagenesis screens in mice to identify
oncogenic networks.
Kool J, Berns A
Nat Rev Cancer. 2009 Jun; 9(6): 389-99. Review
The patient-centered medical home and nephrology.
DuBose TD Jr, Behrens MT,
Berns A, Davis C, Goldfarb S, Hostetter T,
Klotman P, Linas S, Owens S, Szczech L, Himmelfarb J
J Am Soc Nephrol. 2009 Apr; 20(4): 681-2.
Jump-starting cancer gene discovery.
Uren A,
Berns A
Nat Biotechnol. 2009 Mar; 27(3): 251-2
- 2008
Kras and Hras - What is the difference?
Berns A.
Nat Genet. 2008 Oct;40(10): 1149-50
NCAM-induced focal adhesion assembly: A functional switch upon loss of
E-cadherin
Lehembre F, Yilmaz M, Wicki A, Schomber T, Strittmatter K, Ziegler D,
Kren A, Went P, Derksen PW, Berns A, Jonkers J, Chrisofori G.
EMBO J. 2008 Oct 8;27(19): 2603-15.
Need for global action for cancer control
Boyle P, Anderson BO, Andersson LC, Ariyaratne Y, Auleley GR, Barbacid
M, Bartelink H, Baselga J, Behbehani K, Belardelli F, Berns A, Bishop J,
Brawley O, Burns H, Clanton M, Cox B, Currow D, Dangou JM, de Valeriola
D, Dinshaw K, Eggermont A, Fitzpatrick J, Forstmane M, Garaci E, Gavin
AT, Kakizoe T, Kasler M, Keita N, Kerr D, Khayat D, Khleif S, Khuhaprema
T, Knezevic T, Kubinova R, Mallath M, Martin-Moreno J, McCance D, McVie
JG, Merriman A, Ngoma T, Nowacki M, Orgelbrand J, Park JG, Pierotti M,
Aston LP, Puska P, Escobar CV, Rajan B, Rajkumar T, Ringborg U,
Robertson C, Rodger A, Roovali L, Santini LA, Sarhan M, Seffrin J,
Semiglazov V, Shrestha BM, Soo KC, Stamenic V, Tamblyn C, Thomas R,
Tuncer M, Tursz T, Vaitkiene R, Vallejos C, Veronesi U, Wojtyla A, Yach
D, Yoo KY, Zatonski W, Zaridze D, Zeng YX, ZhaoP, Zheng T
Ann Oncol. 2008 Sep;19(9): 1519-21
Large-Scale Mutagenesis in p19ARF- and p53-Deficient Mice Identifies
Cancer Genes and Their Collaborative Networks
Cell. 2008 May;133(1):727-741.
Uren A.G, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M,
Lagcher W, Sie D, Tanger E, Cox T, Reinders M, Hubbard T.J, Rogers J,
Jonkers J, Wessels L, Adams D.J, van Lohuizen M, and Berns A.
Cell. 2008 May;133(1):727-741.
A tRNA with oncogenic capacity.
Berns A
Cell. 2008 April;133(1):29-30.
A Conditional Mouse Model for Malignant Mesothelioma.
Jongsma J, van Montfort E, Vooijs M, Zevenhoven J, Krimpenfort P, van
der Valk M, van de Vijver M, Berns A.
Cancer Cell. 2008 March;13(3):261-271.
Targeted anticancer therapies: mouse models help uncover the mechanisms
of tumor escape.
van Amerongen R, Berns A.
Cancer Cell. 2008 Jan;13(1):5-7.
- 2007
Pim-1 regulates cardiomyocyte survival downstream of Akt.
Nat Med. 2007 Nov 25
Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G,
Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer
K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns
A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA.
p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a.
Nature. 2007 Aug 23;448(7156):943-6.
Krimpenfort P, Ijpenberg A, Song JY, van der Valk M, Nawijn M,
Zevenhoven J, Berns A.
Mouse models of prostate adenocarcinoma with the capacity to monitor
spontaneous carcinogenesis by bioluminescence or fluorescence.
Cancer Res. 2007 Aug 1;67(15):7525-33.
Liao CP, Zhong C, Saribekyan G, Bading J, Park R, Conti PS, Moats R,
Berns A, Shi W, Zhou Z, Nikitin AY, Roy-Burman P.
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with
features of human BRCA1-mutated basal-like breast cancer.
Proc Natl Acad Sci U S A. 2007 Jul 11
Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds
A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers
J.
Cost, quality and value: the changing political economy of dialysis care
J Am Soc Nephrol. 2007 Jul; 18(7): 2021-7
Himmelfarb J, Berns A, Szczech L, Wesson D.
Toxicity of ligand-dependant Cre-recombinases and generation of a
conditional Cre-deleter mouse allowing mosaic recombination in
peripheral tissues.
Physiol Genomics. 2007 Apr 24
Hameyer D, Loonstra A, Eshkind L, Schmitt S, Antunes C, Groen A,
Bindels E, Jonkers J, Krimpenfort P, Meuwissen R, Rijswijk L, Bex A,
Berns A, Bockamp E
- 2006
Knockout mouse models to study Wnt signal transduction.
Trends Genet. 22(12): 678-689.
van Amerongen R and Berns A.
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic
lobular mammary carcinoma through induction of anoikis resistance and
angiogenesis.
Cancer Cell. 2006 Nov;10(5):437-49.
Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B,
van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff
RD, Berns A, Jonkers J.
Cancer biology: can less be more for p53?
2006 Sep 14;443(7108):153-4.
Berns A.
TXR1-mediated thrombospondin repression: a novel mechanism of resistance
to taxanes?
Genes Dev. 2006 Aug 1;20(15):1975-81.
van Amerongen R and Berns A.
Cross-species oncogenomics in cancer gene identification.
Cell. 2006 Jun 30;125(7):1230-3.
Peeper D and Berns A.
Tobacco: deadly in any form or disguise.
Lancet. 2006 May 27;367(9524):1710-2.
Boyle P, Ariyaratne MA, Barrington R, Bartelink H, Bartsch G, Berns
A, de Valeriola D, Dinshaw KA, Eggermont AM, Gray N, Kakizoe T,
Karki BS, Kaslar M, Kerr DJ, Khayat D, Khuhaprema T, Kim IH,
Martin-Moreno J, McVie G, Park JG, Philip T, Ringborg U, Rodger A,
Seffrin JR, Semiglazov V, Soo KC, Sun YT, Thomas R, Tursz T,
Veronesi U, Wiestler O, Yoo KY, Zatonski W, Zhao P.
Lack of Rb and p53 Delays Cerebellar Development and Predisposes to
Large Cell Anaplastic Medulloblastoma through Amplification of N-Myc and
Ptch2.
Cancer Res. 2006 May 15;66(10):5190-200
Shakhova O, Leung C, van Montfort E, Berns A, Marino S.
An Inducible Mouse Model of Melanoma Expressing a Defined Tumor Antigen.
Cancer Research 2006 Mar 15;66(6):3278-3286.
Huijbers IJ, Krimpenfort P, Chomez P, van der Valk MA, Song JY,
Inderberg-Suso EM, Schmitt-Verhulst AM, Berns A, Van den Eynde BJ.
- 2005
Genotype-Phenotype Relationships in a Mouse Model for Human Small-Cell.
Lung Cancer. Cold Spring Harb Symp Quant Biol. 2005;70:225-232.
Calbo J, Meuwissen R, Montfort EV, Tellingen OV, Berns A.
Immunogenicity, including vitiligo, and feasibility of vaccination with
autologous GM-CSF-transduced tumor cells in metastatic melanoma
patients.
J Clin Oncol. 2005 Dec 10;23(35):8978-91.
Luiten RM, Kueter EW, Mooi W, Gallee MP, Rankin EM, Gerritsen WR,
Clift SM, Nooijen WJ, Weder P, van de Kasteele WF, Sein J, van den
Berk PC, Nieweg OE, Berns A, Spits H, de Gast GC.
Retroviral insertional mutagenesis: past, present and future.
Oncogene 2005 Nov 21;24(52):7656-72.
Uren AG, Kool J, Berns A and van Lohuizen M.
Cancer: two in one.
Nature. 2005 Aug 11;436(7052):787-9.
Berns A.
Re-Evaluating the Role of Frat in Wnt-Signal Transduction.
Cell Cycle. 2005 Aug 1;4(8): 1065-1072.
van Amerongen R and Berns A.
Targeted biallelic inactivation of Pten in the mouse prostate leads to
prostate cancer accompanied by increased epithelial cell proliferation
but not by reduced apoptosis.
Cancer Res. 2005 Jul 1;65(13):5730-9.
Ma X, Ziel-van der Made AC, Autar B, van der Korput HA, Vermeij M,
van Duijn P, Cleutjens KB, de Krijger R, Krimpenfort P, Berns A, van
der Kwast TH, Trapman J.
Curbing tobacco's toll starts with the professionals: World No Tobacco
Day
Lancet. 2005 Jun 11-17; 365(9476): 1990-2.
Boyle P, Ariyaratne M, Bartelink H, Baselga J, Berns A, Brawley OW,
Burns H, Davidov M, Dinshaw KA, Dresler C, Eggermont AM, Gajurel D,
Gordina G, Gray N, Kakizoe T, Karki BS, Kásler M, Kerr DJ, Khayat D,
Kiselev A, Khuhaprema T, Klocker H, Levshin V, Martin-Moreno JM,
McVie JG, Mendelsohn J, Napalkov NP, Ngoma TA, Park JG, Philip T,
Pötschke-Langer M, Poudal HN, Rajan B, Ringborg U, Rodger A, Seffrin
JR, Shanta V, Shrestha MM, Thomas R, Tursz T, de Valeriola D,
Veronesi U, Wiestler OD, Zaridze D, Zatonski W, Zeng YX.
Stem cells for lung cancer?
Cell. 2005 Jun 17;121(6):811-3.
Berns A.
Mouse models for human lung cancer.
Genes Dev. 2005 Mar 15;19(6):643-64.
Meuwissen R and Berns A.
Mouse lung neuroendocrine carcinomas: distinct morphologies, same
transcription factors.
Exp Lung Res. 2005 Jan-Feb;31(1):37-55.
Linnoila RI, Naizhen X, Meuwissen R, Berns A, DeMayo FJ.
Frat is dispensable for canonical Wnt signaling in mammals.
Genes Dev. 2005 19: 425-430.
van Amerongen R, Nawijn M, Franca-Koh J, Zevenhoven J, van der
Gulden H, Jonkers J, Berns A.
- 2004
Oncogene addiction; Sometimes a temporary slavery.
Cancer Cell. 2004 Dec;6(6):535-8.
Jonkers J and Berns A.
The European dimension for the mouse genome mutagenesis program.
Nat Genet. 2004 Sep;36(9):925-7.
Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M,
Berns A, Bradley A, Brown S, Carmeliet P, Chambon P, Cox R, Davidson
D, Davies K, Duboule D, Forejt J, Granucci F, Hastie N, de Angelis
MH, Jackson I, Kioussis D, Kollias G, Lathrop M, Lendahl U,
Malumbres M, von Melchner H, Müller W, Partanen J,
Ricciardi-Castagnoli P, Rigby P, Rosen B, Rosenthal N, Skarnes B,
Stewart AF, Thornton J, Tocchini-Valentini G, Wagner E, Wahli W,
Wurst W.
Mice Deficient for All PIM Kinases Display Reduced Body Size and
Impaired Responses to Hematopoietic Growth Factors.
Mol Cell Biol. 2004 Jul;24(13):6104-15.
Mikkers H, Nawijn M, Allen J, Brouwers C, Verhoeven E, Jonkers J,
Berns A.
Synergy of Nf2 and p53 mutations in development of malignant tumours of
neural crest origin.
Oncogene. 2004 Aug 26;23(39):6541-7.
Robanus-Maandag E, Giovannini M, van der Valk M, Niwa-Kawakita M,
Abramowski V, Antonescu C, Thomas G, Berns A.
Unique and overlapping functions of pRb and p107 in the control of
proliferation and differentiation in epidermis.
Development. 2004 Jun;131(11):2737-48.
Ruiz S, Santos M, Segrelles C, Leis H, Jorcano JL, Berns A, Paramio
JM, Vooijs M.
Characterization and functional analysis of the murine Frat2 gene.
J Biol Chem. 2004 Jun 25;279(26):26967-74.
van Amerongen R, van der Gulden H, Bleeker F, Jonkers J, Berns A.
Good news for gene therapy.
N Engl J Med. 2004 Apr 15;350(16):1679-80.
Berns A
More publications from our lab, can be found in
PubMed.
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