NEWS

OCTOBER 2012

The European Research Council (ERC) awards a Starting Grant for project on viral host factors.

 

FEBRUARY 2011

Jan Carette a former postdoc in the Brummelkamp lab starts his own lab at Stanford University. Jan will focus on the identification of host genes that play critical roles in the pathogenesis of infectious agents including viruses.

JANUARY 2011

The Brummelkamp Lab leaves Cambridge (USA) and moves from the Whitehead Institute for Biomedical Research to Amsterdam to set up the new lab at the Netherlands Cancer Institute.

MAY 2011

“Global gene disruption in human cells to assign genes to phenotypes by deep sequencing” -Carette et al. publishes phenotypic interrogation via tag sequencing (PhITSeq) method to examine millions of mutant alleles by parallel sequencing in Nature Biotechnology.

AUGUST 2011

A Haploid Genetic Screen deciphers the entry route of Ebola virus, one of the most lethal viruses. The screen unexpectedly pointed out the cholesterol transporter NPC1. Mutations in NPC1 cause a rare genetic disorder, Niemann-Pick disease, and cells from such patients completely resist infection by Ebola or Marburg viruses (Nature 477).

SEPTEMBER 2011

A haploid genetic screen points out the host cell receptor used by Clostridium difficile binary toxin. C. difficile is the most frequent cause of infectious diarrhea in hospitals worldwide. Hypervirulent strains produce a binary toxin called C. difficile transferase. In collaboration with the laboratory of Klaus Aktories a receptor for this toxin was identified.

AUGUST 2012

Thijn Brummelkamp receives the Molecular Biosystems Early Career Award at the 13th International meeting for Systems Biology in Toronto.

MARCH 2012

Miller et al describe that NPC1 acts as intracellular entry receptor for Ebola virus. The Ebola glycoprotein binds a domain of NPC1 (loop C) to escape from lysosomes. This interaction explains tropism of the virus: expression of human NPC1 makes non-permissive reptilian cells sensitive to infection.