Welcome to the website of the Jacqueline Jacobs laboratory at the Division of Molecular Oncology at the Netherlands Cancer Institute in Amsterdam.
We are interested in ‘Telomere damage and cancer’.
Telomeres are specialized nucleoprotein elements at chromosome ends that help maintain the integrity of our genome.
Telomeres consist of TTAGGG DNA repeats and a unique set of proteins, called shelterin,
that protect natural chromosome ends from being recognized and processed as broken DNA ends.
Insufficient telomere length leading to insufficient concentration of shelterin at chromosome ends, or otherwise impaired shelterin function,
causes telomere deprotection. Loss of telomere protection has important consequences for aging and for the development of cancer.
The aim of our research is to understand the molecular mechanisms underlying this.
For further information check out our research pages.