Publications

Below you will find our key publications. Check PubMed for more publications by Maarten van Lohuizen.

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant Glioma-stem cell homeostasis.
*Gargiulo G, *Cesaroni M, Serresi M, de Vries N, Hulsman D, Gruggeman SW, Lancini C, van Lohuizen M.
Cancer Cell. 2013;23:660-76

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.
Sparmann A, Xie Y, Verhoeven E, Vermeulen M, Lancini C, Gargiulo G, Hulsman D, Mann, M, Knoblich JA, van Lohuizen M.
EMBO J. 2013;32:1598-612

PRC1 coordinates timing of sexual differentiation of female primordial germ cells.
Yokobayashi S, Liang CY, Kohler H, Nestorov P, Liu Z, Vidal M, van Lohuizen M, Roloff TC, Peters AH.
Nature. 2013; 495: 236-40.

Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.
Zencak D, Schouwey K, Chen D, Ekström P, Tanger E, Bremner R, van Lohuizen M, Arsenijevic Y.
Proc Natl Acad Sci USA. 2013; 110: E593-601.

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.
Klijn C, Koudijs MJ, Kool J, ten Hoeve J, Boer M, de Moes J, Akhtar W, van Miltenburg M, Vendel-Zwaagstra A, Reinders MJ, Adams DJ, van et al.
PLoS One. 2013;8:62113

Chromatin position effects assayed by thousands of reporters integrated in parallel.
Akhtar W, de Jong J, Pindyurin AV, Pagie L, Meuleman W, de Ridder J, Berns A, Wessels LF, van Lohuizen M, van Steensel B.
Cell. 2013;154:914-27

The Polycomb group protein Ring1b is essential for pectoral fin development.
van der Velden YU, Wang L, van Lohuizen M, Haramis AP.
Development. 2012 Jun;139(12):2210-20. PubMed PMID: 22619390.

GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.
Westerman BA, Blom M, Tanger E, van der Valk M, Song JY, van Santen M, Gadiot J, Cornelissen-Steijger P, Zevenhoven J, Prosser HM, Uren A, Aronica E, van Lohuizen M.
PLoS One. 2012;7(5):e35943. Epub 2012 May . PubMed PMID: 22574128; PubMed Central PMCID: PMC3344841.

Chromosome conformation capture on chip in single Drosophila melanogaster tissues.
Tolhuis B, Blom M, van Lohuizen M.
Methods. 2012 Apr 16. [Epub ahead of print] PubMed PMID: 22525789.

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.
Nacerddine K, Beaudry JB, Ginjala V, Westerman B, Mattiroli F, Song JY, van der Poel H, Ponz OB, Pritchard C, Cornelissen-Steijger P, Zevenhoven J, Tanger E, Sixma TK, Ganesan S,
van Lohuizen M.
J Clin Invest. 2012 May 1;122(5):1920-32. doi:10.1172/JCI57477. Epub 2012 Apr 16. PubMed PMID: 22505453; PubMed Central PMCID: PMC3336972.

Polycomb function during oogenesis is required for mouse embryonic development.
Posfai E, Kunzmann R, Brochard V, Salvaing J, Cabuy E, Roloff TC, Liu Z, Tardat M, van Lohuizen M, Vidal M, Beaujean N, Peters AH.
Genes Dev. 2012 May 1;26(9):920-32. Epub 2012 Apr 12. PubMed PMID: 22499591; PubMed Central PMCID:PMC3347790.

Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression.
Baradaran-Heravi A, Cho KS, Tolhuis B, Sanyal M, Morozova O, Morimoto M, Elizondo LI, Bridgewater D, Lubieniecka J, Beirnes K, Myung C, Leung D, Fam HK, Choi K, Huang Y, Dionis KY, Zonana J, Keller K, Stenzel P, Mayfield C, Lücke T, Bokenkamp A, Marra MA, van Lohuizen M, Lewis DB, Shaw C, Boerkoel CF.
Hum Mol Genet. 2012 Jun 1;21(11):2572-87. Epub 2012 Feb 28. PubMed PMID: 22378147; PubMed Central PMCID: PMC3349428.

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.
Martin N, Benhamed M, Nacerddine K, Demarque MD, van Lohuizen M, Dejean A, Bischof O.
EMBO J. 2011 Oct 14;31(1):95-109. doi:10.1038/emboj.2011.370. PubMed PMID: 22002537; PubMed Central PMCID: PMC3252579.

A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.
Westerman BA, Braat AK, Taub N, Potman M, Vissers JH, Blom M, Verhoeven E, Stoop H, Gillis A, Velds A, Nijkamp W, Beijersbergen R, Huber LA, Looijenga LH, van Lohuizen M.
J Exp Med. 2011 Dec 19;208(13):2675-89. Epub 2011 Dec 5. PubMed PMID: 22143885; PubMed Central PMCID:PMC3244037.

Computational identification of insertional mutagenesis targets for cancer gene discovery.
de Jong J, de Ridder J, van der Weyden L, Sun N, van Uitert M, Berns A, van Lohuizen M, Jonkers J, Adams DJ, Wessels LF.
Nucleic Acids Res.2011 Aug;39(15):e105. Epub 2011 Jun 7. PubMed PMID: 21652642; PubMed Central PMCID: PMC3159484.

Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells.
Smith LL, Yeung J, Zeisig BB, Popov N, Huijbers I, Barnes J, Wilson AJ, Taskesen E, Delwel R, Gil J, Van Lohuizen M, So CW.
Cell Stem Cell. 2011 Jun 3;8(6):649-62. PubMed PMID: 21624810.

Interactions among Polycomb domains are guided by chromosome architecture.
Tolhuis B, Blom M, Kerkhoven RM, Pagie L, Teunissen H, Nieuwland M, Simonis M, de Laat W, van Lohuizen M, van Steensel B.
PLoS Genet. 2011 Mar;7(3):e1001343. Epub 2011 Mar 24. PubMed PMID: 21455484; PubMed Central PMCID: PMC3063757.

BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair.
Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill SJ, Yao M, Citterio E, van Lohuizen M, Ganesan S.
Mol Cell Biol. 2011 May;31(10):1972-82. Epub 2011 Mar 7. PubMed PMID: 21383063; PubMed Central PMCID:PMC3133356.

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.
van der Velden YU, Wang L, Zevenhoven J, van Rooijen E, van Lohuizen M, Giles RH, Clevers H, Haramis AP.
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4358-63. Epub 2011 Mar 1. PubMed PMID: 21368212; PubMed Central PMCID:PMC3060253.

Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation.
Peric-Hupkes D, Meuleman W, Pagie L, Bruggeman SW, Solovei I, Brugman W, Gräf S, Flicek P, Kerkhoven RM, van Lohuizen M, Reinders M, Wessels L, van Steensel B.
Mol Cell. 2010 May 28;38(4):603-13.

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.
de Vries NA, Bruggeman SW, Hulsman D, de Vries HI, Zevenhoven J, Buckle T, Hamans BC, Leenders WP, Beijnen JH, van Lohuizen M, Berns AJ, van Tellingen O.
Clin Cancer Res. 2010 Jul 1;16(13):3431-41.

Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach.
Mattison J, Kool J, Uren AG, de Ridder J, Wessels L, Jonkers J, Bignell GR, Butler A, Rust AG, Brosch M, Wilson CH, van der Weyden L, Largaespada DA, Stratton MR, Futreal PA, van Lohuizen M, Berns A, Collier LS, Hubbard T, Adams DJ.
Cancer Res. 2010 Feb 1;70(3):883-95. Epub 2010 Jan 26.

Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.
Kool J, Uren AG, Martins CP, Sie D, de Ridder J, Turner G, van Uitert M, Matentzoglu K, Lagcher W, Krimpenfort P, Gadiot J, Pritchard C, Lenz J, Lund AH, Jonkers J, Rogers J, Adams DJ, Wessels L, Berns A, van Lohuizen M.
Cancer Res. 2010 Jan 15;70(2):520-31. Epub 2010 Jan 12.