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Selected articles

kuilman7

Phenotypic diversity drives paracrine drug tolerance


Kuilman, T. and D.S. Peeper
EMBO Molecular Medicine, 2017. pii: e201707956

This article in Pubmed


gallenne

Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer


Gallenne, T., K.N. Ross, N.L. Visser, Salony, C.J. Desmet, B.S. Wittner, L.F.A. Wessels, S. Ramaswamy and D.S. Peeper
Oncotarget, 2017. 8(13): p. 20572-20587

This article in Pubmed


kemper4

BRAF(V600E) kinase domain duplication identified in therapy-refractory melanoma patient-derived xenografts


Kemper, K., O. Krijgsman, X. Kong, P. Cornelissen-Steijger, A. Shahrabi, F. Weeber, D.L. van der Velden, O.B. Bleijerveld, T. Kuilman, R.J. Kluin, C. Sun, E.E. Voest, Y.S. Ju, T.N. Schumacher, A.F. Altelaar, U. McDermott, D.J. Adams, C.U. Blank, J.B. Haanen and D.S. Peeper
Cell Reports, 2016. 16(1): p. 263-277

This article in Pubmed


iskit2

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer


Iskit, S., C. Lieftink, P. Halonen, A. Shahrabi, P.A. Possik, R.L. Beijersbergen and D.S. Peeper
Oncotarget, 2016. 7(28): p. 42859-42872

This article in Pubmed


byrne

Interrogating open issues in cancer precision medicine with patient-derived xenografts


Byrne, A.T., D.G. Alférez, F. Amant, D. Annibali, J. Arribas, A.V. Biankin, A. Bruna, E. Budinská, C. Caldas, D.K. Chang, R.B. Clarke, H. Clevers, G. Coukos, V. Dangles-Marie, S.G. Eckhardt, E. Gonzalez-Suarez, E. Hermans, M. Hidalgo, M.A. Jarzabek, S. de Jong, J. Jonkers, K. Kemper, L. Lanfrancone, G.M. Mælandsmo, E. Marangoni, J.C. Marine, E. Medico, J.H. Norum, H.G. Palmer, D.S. Peeper, P.G. Pelicci, A. Piris-Gimenez, S. Roman-Roman, O.M. Rueda, J. Seoane, V. Serra, L. Soucek, D. Vanhecke, A. Villanueva, E. Vinolo, A. Bertotti and L. Trusolino
Nature Reviews Cancer, 2017. 17(4): p. 254-268

This article in Pubmed


kaplon4

MITF: More Interesting Traits, Folks!


Kemper, K., O. Krijgsman and D.S. Peeper
Pigment Cell Melanoma Research, 2016. 29(3): p. 263-265

This article in Pubmed


kuilman6

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival


Iskit, S., A. Schlicker, L. Wessels and D.S. Peeper
Oncotarget, 2015. 6(41): p. 43146-43161

This article in Pubmed


vogel

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence


Lenain, C., O. Gusyatiner, S. Douma, B. van den Broek and D.S. Peeper
Carcinogenesis, 2015. 36(11): p. 1263-1274

This article in Pubmed


kemper2

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts


Kemper, K., O. Krijgsman, P. Cornelissen-Steijger, A. Shahrabi, F. Weeber, J.Y. Song, T. Kuilman, D.J. Vis, L.F. Wessels, E.E. Voest, T.N. Schumacher, C.U. Blank, D.J. Adams, J.B. Haanen and D.S. Peeper
EMBO Molecular Medicine, 2015. pii: e201404914

This article in Pubmed


kaplon4

Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence


De Graaf, E.L., J. Kaplon, S. Mohammed, L.A. Vereijken, D.P. Duarte, L. Redondo Gallego, A.J. Heck, D.S. Peeper and A.F. Altelaar
Journal of Proteome Research, 2015. 14(7): p. 2906-2914

This article in Pubmed


kuilman6

CopywriteR: DNA copy number detection from off-target sequence data


Kuilman, T., A. Velds, K. Kemper, M. Ranzani, L. Bombardelli, M. Hoogstraat, E. Nevedomskaya, G. Xu, J. de Ruiter, M.P. Lolkema, B. Ylstra, J. Jonkers, S. Rottenberg, L.F. Wessels, D.J. Adams, D.S. Peeper and O. Krijgsman
Genome Biology, 2015. 16:49

This article in Pubmed


vogel

Cooperative induction of apoptosis in nras mutant melanoma by inhibition of mek and rock


Vogel, C.J., M.A. Smit, G. Maddalo, P.A. Possik, R.W. Sparidans, S.H. van der Burg, E.M. Verdegaal, A.J. Heck, A.A. Samatar, J.H. Beijnen, A.F. Altelaar and D.S. Peeper
Pigment Cell & Melanoma Research, 2015. 28(3): p. 307-317

This article in Pubmed


kuilman5

Detailed imaging and genetic analysis reveal a secondary BRAFL 505H resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib


Hoogstraat, M., C.G. Gadellaa-van Hooijdonk, I. Ubink, N.J. Besselink, M. Pieterse, W. Veldhuis, M. van Stralen, E.F. Meijer, S.M. Willems, M.A. Hadders, T. Kuilman, O. Krijgsman, D.S. Peeper, M.J. Koudijs, E. Cuppen, E.E. Voest and M.P. Lolkema
Pigment Cell & Melanoma Research, 2015. 28(3): p. 318-323

This article in Pubmed


smit6

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma


Smit, M.A., G. Maddalo, K. Greig, L.M. Raaijmakers, P.A. Possik, B. van Breukelen, S. Cappadona, A.J. Heck, A.F. Altelaar and D.S. Peeper
Molecular Systems Biology, 2014. 10:772

This article in Pubmed


mueller

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma


Müller, J., O. Krijgsman, J. Tsoi, L. Robert, W. Hugo, C. Song, X. Kong, P.A. Possik, P.D. Cornelissen-Steijger, M.H. Foppen, K. Kemper, C.R. Goding, U. McDermott, C. Blank, J. Haanen, T.G. Graeber, A. Ribas, R.S. Lo and D.S. Peeper
Nature Communications, 2014. 5:5712

This article in Pubmed


possik3

Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition


Possik, P.A., J. Müller, C. Gerlach, J.C. Kenski, X. Huang, A. Shahrabi, O. Krijgsman, J.Y. Song, M.A. Smit, B. Gerritsen, C. Lieftink, K. Kemper, M. Michaut, R.L. Beijersbergen, L. Wessels, T.N. Schumacher and D.S. Peeper
Cell Reports, 2014. 9(4): p. 1375-1386

This article in Pubmed


kemper

Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy


Kemper, K., P.L. de Goeje, D.S. Peeper, R. van Amerongen
Cancer Research, 2014. 74(21): p. 5937-5941

This article in Pubmed


peeper14

Cancer drug resistance: old concept, novel solutions required


D.S. Peeper
Molecular Oncology, 2014. 8(6): p. 1064-1066

This article in Pubmed


kaplon3

Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence


De Graaf, E.L., J. Kaplon, H. Zhou, A.J. Heck, D.S. Peeper and A.F. Altelaar
Molecular & Cellular Proteomics, 2014. 13(8): p. 2089-2100

This article in Pubmed


kaplon2

Near-genomewide RNAi screening for regulators of BRAF(V600E)-induced senescence identifies RASEF, a gene epigenetically silenced in melanoma


Kaplon, J., C. Hömig-Hölzel, L. Gao, K. Meissl, E.M. Verdegaal, S.H. van der Burg, R van Doorn and D.S. Peeper
Pigment Cell & Melanoma Research, 2014. 27(4): p. 640-652

This article in Pubmed


kuilman4

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells


Biroccio, A., J. Cherfils-Vicini, A. Augereau, S. Pinte, S. Bauwens, J. Ye, T. Simonet, B. Horard, K. Jamet, L. Cervera, A. Mendez-Bermudez, D. Poncet, R. Grataroli, C.T. de Rodenbeeke, E. Salvati, A. Rizzo, P. Zizza, M. Ricoul, C. Cognet, T. Kuilman, H. Duret, F. Lépinasse, J. Marvel, E. Verhoeyen, F.L. Cosset, D. Peeper, M.J. Smyth, A. Londoño-Vallejo, L. Sabatier, V. Picco, G. Pages, J.Y. Scoazec, A. Stoppacciaro, C. Leonetti, E. Vivier and E. Gilson
Nature Cell Biology, 2013. 15(7): p. 818-828

This article in Pubmed


smit5

Genome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma


Gao, L., M.A. Smit, J.J. van den Oord, J.J. Goeman, E.M.E. Verdegaal, S.H. van der Burg, M. Stas, S. Beck, N.A. Gruis, C.P. Tensen, R. Willemze, D.S. Peeper and R. van Doorn
Pigment Cell & Melanoma Research, 2013. 26(4): p. 542–554

This article in Pubmed


kaplon

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence


Kaplon, J., L. Zheng, K. Meissl, B. Chaneton, V.A. Selivanov, G. Mackay, S.H. van der Burg, E.M. Verdegaal, M. Cascante, T. Shlomi, E. Gottlieb and D.S. Peeper
Nature, 2013. 498(7452): p. 109-112

This article in Pubmed    Preview in Cell    Research Watch in Cancer Discovery


desmet2

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis


Desmet, C.J., T. Gallenne, A. Prieur, F. Reyal, N.L. Visser, B.S. Wittner, M.A. Smit, T.R. Geiger, J. Laoukili, S. Iskit, B. Rodenko, W. Zwart, B. Evers, H. Horlings, A. Ajouaou, J. Zevenhoven, M. van Vliet, S. Ramaswamy, L.F. Wessels and D.S. Peeper
Proceedings of the National Academy of Sciences, 2013. 110(13): p. 5139-5144

This article in Pubmed    Research Highlight in Nature Reviews Cancer


vredeveld2

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis


Vredeveld, L.C., P.A. Possik, M.A. Smit, K. Meissl, C. Michaloglou, H.M. Horlings, A. Ajouaou, P.C. Kortman, D. Dankort, M. McMahon, W.J. Mooi and D.S. Peeper
Genes & Development, 2012. 26(10): p. 1055-1069

This article in Pubmed    News & Views in PCMR


peeper13

Oncogene-induced senescence and melanoma: where do we stand?


D.S. Peeper
Pigment Cell & Melanoma Research, 2011. 24(6): p. 1107-1111

This article in Pubmed


possik2

Evidence of oncogene-induced senescence in thyroid carcinogenesis


Vizioli, M.G., P.A. Possik, E. Tarantino, K. Meissl, M.G. Borrello, C. Miranda, M.C. Anania, S. Pagliardini, E. Seregni, M.A. Pierotti, S. Pilotti, D.S. Peeper and A. Greco
Endocrine-Related Cancer, 2011. 18(6): p. 743-757

This article in Pubmed


peeper12

Ageing: Old cells under attack


D.S. Peeper
Nature, 2011. 479(7372): p. 186-187

This article in Pubmed


peeper11

C/EBPβ: lost beyond translation.


D.S. Peeper
EMBO Journal, 2011. 30(18): p. 3663-3664

This article in Pubmed


smit4

Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis


Smit, M.A. and D.S. Peeper
Oncogene, 2011. 30(35): p. 3735-3744

This article in Pubmed


possik

If you can't beat me, join me: collaborating oncogenes circumventing senescence and causing cancer


Possik, P.A. and D.S. Peeper
Pigment Cell & Melanoma Research, 2011. 24(4): p. 586-587.

This article in Pubmed


hoemig

Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence


Hömig-Hölzel, C., R. van Doorn, C. Vogel, M. Germann, M.G. Cecchini, E. Verdegaal and D.S. Peeper
EMBO Journal, 2011. 30(9): p. 1753-1765

This article in Pubmed


geiger4

Functional characterization of human cancer-derived TRKB mutations


Geiger, T.R., J.Y. Song, A. Rosado and D.S. Peeper
PLoS One, 2011. 6(2): e16871

This article in Pubmed


kuilman3

The essence of senescence


Kuilman, T., C. Michaloglou, W.J. Mooi and D.S. Peeper
Genes & Development, 2010. 24(22): p. 2463-2479

This article in Pubmed


smit3

Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths


Smit, M.A. and D.S. Peeper
Aging, 2010. 2(10): p. 735-741

This article in Pubmed


peeper10

PICS-ure this: prosenescence therapy?


D.S. Peeper
Cancer Cell, 2010. 17(3): p. 219-220

This article in Pubmed


peeper9

Impact papers on aging in 2009.


Blagosklonny, M.V., J. Campisi, D.A. Sinclair, A. Bartke, M.A. Blasco, W.M. Bonner, V.A. Bohr, R.M. Brosh Jr, A. Brunet, R.A. Depinho, L.A. Donehower, C.E. Finch, T. Finkel, M. Gorospe, A.V. Gudkov, M.N. Hall, S. Hekimi, S.L. Helfand, J. Karlseder, C. Kenyon, G. Kroemer, V. Longo, A. Nussenzweig, H.D. Osiewacz, D.S. Peeper, T.A. Rando, K.L. Rudolph, P. Sassone-Corsi, M. Serrano, N.E. Sharpless, V.P. Skulachev, J.L. Tilly, J. Tower, E. Verdin and J. Vijg
Aging, 2010. 2(3): p. 111-121

This article in Pubmed


vredeveld

Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E


Vredeveld, L.C., B.D. Rowland, S. Douma, R. Bernards and D.S. Peeper
Carcinogenesis, 2010. 31(2): p. 201-207

This article in Pubmed


geiger3

Metastasis mechanisms


Geiger, T.R. and D.S. Peeper
Biochimica et Biophysica Acta, 2009. 1796(2): p. 293-308

This article in Pubmed


smit2

A Twist–Snail axis critical for TrkB-induced EMT-like transformation, anoikis resistance and metastasis


Smit, M.A., T.R. Geiger, J.Y. Song, I. Gitelman and D.S. Peeper
Molecular and Cellular Biology, 2009. 29(13): p. 3722-3737

This article in Pubmed


prieur2

SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes


Prieur, A., K. Nacerddine, M. van Lohuizen and D.S. Peeper
PLoS ONE, 2009. 4(5): e5542

This article in Pubmed


peeper8

Ras and pRb: the relationship gets yet more intimate


D.S. Peeper
Cancer Cell, 2009. 15(4): p. 243-245

This article in Pubmed


kuilman2

Senescence-messaging secretome: SMS-ing cellular stress


Kuilman, T. and D.S. Peeper
Nature Reviews Cancer, 2009. 9(2): p. 81-94

This article in Pubmed    From the Editors in Nature Reviews Cancer


smit

Deregulating EMT and senescence: double impact by a single twist


Smit, M.A. and D.S. Peeper
Cancer Cell, 2008. 14(1): p. 5-7

This article in Pubmed


kuilman

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network


Kuilman, T., C. Michaloglou, L.C.W. Vredeveld, S. Douma, R. van Doorn, C.J. Desmet, L.A. Aarden, W.J. Mooi and D.S. Peeper
Cell, 2008. 133(6): p. 1019-1031

This article in Pubmed    Research Highlight in Nature Reviews Cancer
News & Views in Nature Cell Biol    Minireview in Cell


prieur

Cellular senescence in vivo: a barrier to tumorigenesis


Prieur, A. and D.S. Peeper
Current Opinion in Cell Biology, 2008. 20(2): p. 150-155

This article in Pubmed


peeper7

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.


Schlisio S, R.S. Kenchappa, L.C. Vredeveld, R.E. George, R. Stewart, H. Greulich, K. Shahriari, N.V. Nguyen, P. Pigny, P.L. Dahia, S.L. Pomeroy, J.M. Maris, A.T. Look, M. Meyerson, D.S. Peeper, B.D. Carter BD and W.G. Kaelin Jr.
Genes & Development, 2008. 22(7): p. 884-893

This article in Pubmed


michaloglou2

BRAFE600 in benign and malignant human tumours


Michaloglou, C., L.C. Vredeveld, W.J. Mooi and D.S. Peeper
Oncogene, 2007. 27(7): p. 877-895

This article in Pubmed


geiger2

Critical role for TrkB kinase function in anoikis suppression, tumorigenesis and metastasis


Geiger, T.R. and D.S. Peeper
Cancer Research, 2007. 67(13): p. 6221-6229

This article in Pubmed


peeper6

Oncogene-induced cell senescence--halting on the road to cancer


Mooi, W.J. and D.S. Peeper
The New England Journal of Medicine, 2006. 355(10): p. 1037-1046

This article in Pubmed


peeper5

Cross-species oncogenomics in cancer gene identification


Peeper, D. and A. Berns
Cell, 2006. 125(7): p. 1230-1233

This article in Pubmed


desmet

The neurotrophic receptor TrkB: a drug target in anti-cancer therapy


Desmet, C.J. and D.S. Peeper
Cellular and Molecular Life Sciences, 2006. 63(7-8): p. 755-759

This article in Pubmed


rowland3

KLF4, p21 and context-dependent opposing forces in cancer


Rowland, B.D. and D.S. Peeper
Nature Reviews Cancer, 2006. 6(1): p. 11-23

This article in Pubmed


rowland2

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene


Rowland, B.D., R. Bernards and D.S. Peeper
Nature Cell Biology, 2005. 7(11): p. 1074-1082

This article in Pubmed    Highlight in Nature
Research Highlight in Nature Reviews Cancer


geiger

The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective


Geiger, T.R. and D.S. Peeper
Cancer Research, 2005. 65(16): p. 7033-7036

This article in Pubmed


michaloglou

BRAFE600-associated senescence-like cell cycle arrest of human naevi


Michaloglou, C., L.C. Vredeveld, M.S. Soengas, C. Denoyelle, T. Kuilman, C.M. van der Horst, D.M. Majoor, J.W. Shay, W.J. Mooi and D.S. Peeper
Nature, 2005. 436(7051): p. 720-724

This article in Pubmed    News & Views in Nature
Perspective in Science    Research Highlight in Nature Reviews Cancer


douma

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB


Douma, S., T. Van Laar, J. Zevenhoven, R. Meuwissen, E. Van Garderen and D.S. Peeper
Nature, 2004. 430(7003): p. 1034-1039

This article in Pubmed    News & Views in Nature
Research Highlight in Nature Reviews Cancer


rowland

E2F transcriptional repressor complexes are critical downstream targets of p19ARF/p53-induced proliferative arrest


Rowland, B.D., S.G. Denissov, S. Douma, H.G. Stunnenberg, R. Bernards and D.S. Peeper
Cancer Cell, 2002. 2(1): p. 55-65

This article in Pubmed


peeper4

Pathogenesis of melanocytic naevi: growth arrest linked with cellular senescence?


Mooi, W.J. and D.S. Peeper
Histopathology 41: p. 139S-142S

This article online


peeper3

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence


Peeper, D.S., A. Shvarts, T. Brummelkamp, S. Douma, E.Y. Koh, G.Q. Daley and R. Bernards
Nature Cell Biology, 2002. 4(2): p. 148-153

This article in Pubmed


peeper2

Escape from premature senescence is not sufficient for oncogenic transformation by Ras


Peeper, D.S., J.H. Dannenberg, S. Douma, H. te Riele and R. Bernards
Nature Cell Biology, 2001. 3(2): p. 198-203

This article in Pubmed


peeper

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein


Peeper, D.S., T.M. Upton, M.H. Ladha, E. Neuman, J. Zalvide, R. Bernards, J.A. DeCaprio and M.E. Ewen
Nature, 1997. 386(6621): p. 177-181

This article in Pubmed