About

Alfred Schinkel
(Group leader)

Mouse models for drug resistance, drug transport and drug metabolism

The behavior of drugs in the body is critically dependent on proteins that transport or metabolize drugs. Variation in activity of these proteins due to overexpression in tumors, genetic polymorphisms, or inhibition or induction by (other) drugs and food components plays a major role in efficacy and toxic side effects of pharmacotherapy. We aim to obtain basic insight into the in vivo functions of the most important drug-transporting and drug-metabolizing proteins by generating and studying knockout and transgenic mice. Analysis of these mice provides insight into physiological, pharmacological and toxicological functions of these detoxifying proteins. The insights and models obtained allow the design and testing of optimized drug treatment regimens and support development of new drugs for cancer and numerous other diseases.

For further information check out our research pages.



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