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Our lab is interested in how chromatin proteins can control gene expression
programs. The
coordinated regulation of thousands of genes in a eukaryotic cell involves
a huge number of interactions between hundreds of chromatin proteins and
their target genes. Understanding these complex networks of interactions
will require new experimental and conceptual approaches. |
Chromatin profiling
We
design and apply whole-genome
technologies to study the interactions of regulatory proteins with their
target genes. We have developed DamID,
a novel approach for large-scale mapping of in vivo protein-DNA interactions. New whole-genome methods to study
chromatin structure are under development. |
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Gene
expression
Our biological interest is focussed on protein complexes involved in
control of transcription. We use chromatin profiling, expression
profiling, and other approaches to identify target genes of regulatory
complexes and to study the molecular mechanisms of gene regulation. We use
both Drosophila and mammalian cell systems. |
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Bioinformatics
Whole-genome datasets cannot be interpreted without the help of
bioinformatics. We are
developing analytical tools to extract relevant biological information
from DamID, expression profiling and other datasets. |
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This website is created by
Tom de Knegt |
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van
Steensel lab