Click here for full PubMed list



2017

Genome-wide mapping of autonomous promoter activity in human cells
Van Arensbergen J*, FitzPatrick VD, de Haas M, Pagie L, Sluimer J, Bussemaker HJ*, van Steensel B*. *co-corresponding authors
Nature Biotechnol. 2017 Feb;35(2):145-153
Genome - nuclear lamina interactions: from cell populations to single cells
Yáñez-Cuna JO, van Steensel B.
Curr Opin Genet Dev. 2017 Jan 17;43:67-72

2016

High-throughput assessment of context-dependent effects of chromatin proteins.
Brueckner L, van Arensbergen J, Akhtar W, Pagie L, van Steensel B.
Epigenetics & Chromatin 2016;9:43
A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin.
Janssen A, Breuer GA, Brinkman EK, van der Meulen AI, Borden SV, van Steensel B, Bindra RS, LaRocque JR, Karpen GH.
Genes Dev. 2016;30:1645-1657
Inducible DamID systems for genomic mapping of chromatin proteins in Drosophila
Pindyurin AV*, Pagie L, Kozhevnikova EN, van Arensbergen J, van Steensel B* (*co-corresponding authors)
Nucleic Acids Res. 2016;44:5646-57

2015

GENE REGULATION. A HUSH for transgene expression.
Brummelkamp TR, van Steensel B.
Science 2015;348:1433-1434
Genome-wide maps of nuclear lamina interactions in single human cells.
Kind J, Pagie L, de Vries SS, Nahidiazar L, Dey SS, Bienko M, Zhan Y, Lajoie B, de Graaf CA, Amendola M, Fudenberg G, Imakaev M, Mirny LA, Jalink K, Dekker J, van Oudenaarden A, van Steensel B.
Cell 2015;163:134-147
A short guide to technology development in cell biology.
van Steensel B.
J Cell Biol. 208:655-657.

2014

Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans.
Sharma R, Jost D, Kind J, Gómez-Saldivar G, van Steensel B, Askjaer P, Vaillant C, Meister P.
Genes Dev. 28:2591-2596.
Easy quantitative assessment of genome editing by sequence trace decomposition.
Brinkman EK, Chen T, Amendola M, van Steensel B
Nucleic Acids Res. 42:e168.
In search of the determinants of enhancer-promoter interaction specificity.
van Arensbergen J, van Steensel B, Bussemaker HJ.
Trends Cell Biol. 24:695-702.
Using TRIP for genome-wide position effect analysis in cultured cells.
Akhtar W, Pindyurin AV, de Jong J, Pagie L, Ten Hoeve J, Berns A, Wessels LF, van Steensel B, van Lohuizen M.
Nat Protoc. 9:1255-1281.
Domains of genome-wide gene expression dysregulation in Down's syndrome.
Letourneau A, Santoni FA, Bonilla X, Sailani MR, Gonzalez D, Kind J, Chevalier C, Thurman R, Sandstrom RS, Hibaoui Y, Garieri M, Popadin K, Falconnet E, Gagnebin M, Gehrig C, Vannier A, Guipponi M, Farinelli L, Robyr D, Migliavacca E, Borel C, Deutsch S, Feki A, Stamatoyannopoulos JA, Herault Y, van Steensel B, Guigo R, Antonarakis SE.
Nature 508:345-350.
Mechanisms and dynamics of nuclear lamina-genome interactions.
Amendola M, van Steensel B.
Curr Opin Cell Biol. 28C:61-68.

2013

Chromatin position effects assayed by thousands of reporters integrated in parallel.
Akhtar W, de Jong J, Pindyurin AV, Pagie L, Meuleman W, de Ridder J, Berns A, Wessels LF, van Lohuizen M, van Steensel B.
Cell. 2013 Aug 15;154(4):914-27.
Differential programming of B cells in AID deficient mice.
Hogenbirk MA, Heideman MR, Velds A, van den Berk PC, Kerkhoven RM, van Steensel B, Jacobs H.
PLoS One. 2013 Jul 29;8(7):e69815.
The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells.
Izzo A, Kamieniarz-Gdula K, Ramírez F, Noureen N, Kind J, Manke T, van Steensel B, Schneider R.
Cell Rep. 2013 Jun 27;3(6):2142-54.
Single-cell dynamics of genome-nuclear lamina interactions.
Kind J, Pagie L, Ortabozkoyun H, Boyle S, de Vries SS, Janssen H, Amendola M, Nolen LD, Bickmore WA, van Steensel B.
Cell. 2013 Mar 28;153(1):178-92.
Genome architecture: domain organization of interphase chromosomes.
Bickmore WA, van Steensel B.
Cell. 2013 Mar 14;152(6):1270-84.
A network model of the molecular organization of chromatin in Drosophila.
van Bemmel JG, Filion GJ, Rosado A, Talhout W, de Haas M, van Welsem T, van Leeuwen F, van Steensel B.
Mol Cell. 2013 Feb 21;49(4):759-71.
Cromatin organization: form to function.
de Graaf CA, van Steensel B.
Curr Opin Genet Dev. 2013 Apr;23(2):185-90.
Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence.
Meuleman W, Peric-Hupkes D, Kind J, Beaudry JB, Pagie L, Kellis M, Reinders M, Wessels L, van Steensel B.
Genome Res. 2013 Feb;23(2):270-80.

2012

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.
van Luenen HG, Farris C, Jan S, Genest PA, Tripathi P, Velds A, Kerkhoven RM, Nieuwland M, Haydock A, Ramasamy G, Vainio S, Heidebrecht T, Perrakis A, Pagie L, van Steensel B, Myler PJ, Borst P.
Cell. 2012 Aug 31;150(5):909-21.
Mapping of lamin A- and progerin-interacting genome regions.
Kubben N, Adriaens M, Meuleman W, Voncken JW, van Steensel B, Misteli T.
Chromosoma. 2012 Oct;121(5):447-64.
Hox in space: gene cluster regulation linked to folding of chromatin.
Pindyurin AV, van Steensel B.
Nucleus. 2012 Mar 1;3(2):118-22.

2011

Chromatin: constructing the big picture.
B van Steensel
EMBO J. May 18 2011, 30(10):1885-95
Interactions among Polycomb domains are guided by chromosome architecture.
B Tolhuis, M Blom, RM Kerkhoven, L Pagie, H Teunissen, M Nieuwland, M Simonis, W de Laat, M van Lohuizen, B van Steensel
PLoS Genet. Mar 2011, 7(3):e1001343

2010

Role of the nuclear lamina in genome organization and gene expression.
D Peric-Hupkes, B van Steensel
Cold Spring Harbor Symp. Quant. Biol. 2010, 75:517-24
The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome.
JG van Bemmel, L Pagie, U Braunschweig, W Brugman, W Meuleman, RM Kerkhoven, B van Steensel
PloS ONE. 2010, 5(11):e15013
Genomics tools for unraveling chromosome architecture.
B van Steensel, J Dekker
Nature Biotechnol. Oct 13 2010, 28(10):1089-1095
A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands.
A Pauli, JG van Bemmel, RA Oliveira, T Itoh, K Shirahige, B van Steensel, K Nasmyth
Current Biol. Oct 26 2010, 20(20):1787-98
Systematic protein location mapping reveals five principal chromatin types in Drosophila cells.
GJ Filion, JG van Bemmel, U Braunschweig, W Talhout, J Kind, LD Ward, W Brugman, IJ de Castro, RM Kerkhoven, HJ Bussemaker, B van Steensel
Cell. Oct 15 2010, 143(2):212-24
Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation.
D Peric-Hupkes, W Meuleman, L Pagie, SW Bruggeman, I Solovei, W Brugman, S Gräf, P Flicek, RM Kerkhoven, M van Lohuizen, M Reinders, L Wessels, B van Steensel
Mol. Cell. May 28 2010, 38(4):603-13
Genome-nuclear lamina interactions and gene regulation.
J Kind, B van Steensel
Current Opin. Cell Biol. Jun 2010, 22(3):320-5
Reassessing the abundance of H3K9me2 chromatin domains in embryonic stem cells.
GJ Filion, B van Steensel
Nature Genet. Jan 2010, 42(1):4; author reply 5-6
Bayesian network analysis of targeting interactions in chromatin.
B van Steensel, U Braunschweig, GJ Filion, M Chen, JG van Bemmel, T Ideker
Genome Res. Feb 2010, 20(2):190-200

2009

Histone H1 binding is inhibited by histone variant H3.3.
U Braunschweig, GJ Hogan, L Pagie, B van Steensel
EMBO J. Dec 2 2009, 28(23):3635-45
High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model.
MJ Vogel, L Pagie, W Talhout, M Nieuwland, RM Kerkhoven, B van Steensel
Epigenetics & Chromatin. 2009, 2(1):1
Chromatin domains in higher eukaryotes: insights from genome-wide mapping studies.
E de Wit, B van Steensel
Chromosoma. Feb 2009, 118(1):25-36

2008

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions.
L Guelen, L Pagie, E Brasset, W Meuleman, MB Faza, W Talhout, BH Eussen, A de Klein, L Wessels, W de Laat, B van Steensel
Nature. Jun 12 2008, 453(7197):948-51
Global chromatin domain organization of the Drosophila genome.
E de Wit, U Braunschweig, F Greil, HJ Bussemaker, B van Steensel
PLoS Genet. Mar 2008, 4(3):e1000045
Linking cohesin to gene regulation.
D Peric-Hupkes, B van Steensel
Cell. Mar 21 2008, 132(6):925-8

2007

SUUR joins separate subsets of PcG, HP1 and B-type lamin targets in Drosophila.
AV Pindyurin, C Moorman, E de Wit, SN Belyakin, ES Belyaeva, GK Christophides, FC Kafatos, B van Steensel, IF Zhimulev
J. Cell Science. Jul 15 2007, 120(Pt 14):2344-51
Detection of in vivo protein-DNA interactions using DamID in mammalian cells.
MJ Vogel, D Peric-Hupkes, B van Steensel
Nature Protoc. 2007, 2(6):1467-78
High-resolution mapping reveals links of HP1 with active and inactive chromatin components.
E de Wit, F Greil, B van Steensel
PLoS Genet. Mar 2 2007, 3(3):e38
HP1 controls genomic targeting of four novel heterochromatin proteins in Drosophila.
F Greil, E de Wit, HJ Bussemaker, B van Steensel
EMBO J. Feb 7 2007, 26(3):741-51

2006

Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells.
SP Choksi, TD Southall, T Bossing, K Edoff, E de Wit, BE Fischer, B van Steensel, G Micklem, AH Brand
Dev. Cell. Dec 2006, 11(6):775-89
Human heterochromatin proteins form large domains containing KRAB-ZNF genes.
MJ Vogel, L Guelen, E de Wit, D Peric-Hupkes, M Lodén, W Talhout, M Feenstra, B Abbas, AK Classen, B van Steensel
Genome Res. Dec 2006, 16(12):1493-504
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C).
M Simonis, P Klous, E Splinter, Y Moshkin, R Willemsen, E de Wit, B van Steensel, W de Laat
Nature Genet. Nov 2006, 38(11):1348-54
DamID: mapping of in vivo protein-genome interactions using tethered DNA adenine methyltransferase.
F Greil, C Moorman, B van Steensel
Meth. Enzymol. 2006, 410:342-59
Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster.
C Moorman, LV Sun, J Wang, E de Wit, W Talhout, LD Ward, F Greil, XJ Lu, KP White, HJ Bussemaker, B van Steensel
Proc. Nat. Acad. Sci. USA. Aug 8 2006, 103(32):12027-32
Characterization of the Drosophila melanogaster genome at the nuclear lamina.
H Pickersgill, B Kalverda, E de Wit, W Talhout, M Fornerod, B van Steensel
Nature Genet. Sep 2006, 38(9):1005-14
Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster.
B Tolhuis, E de Wit, I Muijrers, H Teunissen, W Talhout, B van Steensel, M van Lohuizen
Nature Genet. Jun 2006, 38(6):694-9
Chromosome-wide gene-specific targeting of the Drosophila dosage compensation complex.
GD Gilfillan, T Straub, E de Wit, F Greil, R Lamm, B van Steensel, PB Becker
Genes Dev. Apr 1 2006, 20(7):858-70

2005

Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals.
E de Wit, F Greil, B van Steensel
Genome Res. Sep 2005, 15(9):1265-73
Histone modifications: from genome-wide maps to functional insights.
F van Leeuwen, B van Steensel
Genome Biol. 2005, 6(6):113
Mapping of genetic and epigenetic regulatory networks using microarrays.
B van Steensel
Nature Genet. Jun 2005, 37 Suppl:S18-24
Whole-genome views of chromatin structure.
M Lodén, B van Steensel
Chromosome Res. 2005, 13(3):289-98

2004

2003

Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location.
F Greil, I van der Kraan, J Delrow, JF Smothers, E de Wit, HJ Bussemaker, R van Driel, S Henikoff, B van Steensel
Genes Dev. Nov 15 2003, 17(22):2825-38
Epigenomic profiling using microarrays.
B van Steensel, S Henikoff
BioTechniques. Aug 2003, 35(2):346-50, 352-4, 356-7
Protein-DNA interaction mapping using genomic tiling path microarrays in Drosophila.
LV Sun, L Chen, F Greil, N Negre, TR Li, G Cavalli, H Zhao, B Van Steensel, KP White
Proc. Nat. Acad. Sci. USA. Aug 5 2003, 100(16):9428-33
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.
A Orian, B van Steensel, J Delrow, HJ Bussemaker, L Li, T Sawado, E Williams, LW Loo, SM Cowley, C Yost, S Pierce, BA Edgar, SM Parkhurst, RN Eisenman
Genes Dev. May 1 2003, 17(9):1101-14
Genomewide analysis of Drosophila GAGA factor target genes reveals context-dependent DNA binding.
B van Steensel, J Delrow, HJ Bussemaker
Proc. Nat. Acad. Sci. USA. Mar 4 2003, 100(5):2580-5

2002

Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing.
D Schübeler, D Scalzo, C Kooperberg, B van Steensel, J Delrow, M Groudine
Nature Genet. Nov 2002, 32(3):438-42
Genome-wide profiling of DNA methylation reveals transposon targets of CHROMOMETHYLASE3.
R Tompa, CM McCallum, J Delrow, JG Henikoff, B van Steensel, S Henikoff
Current Biol. Jan 8 2002, 12(1):65-8

2001

Chromatin profiling using targeted DNA adenine methyltransferase.
B van Steensel, J Delrow, S Henikoff
Nature Genet. Mar 2001, 27(3):304-8