Below you will find our key publications. Check PubMed for more publications by Hein te Riele.

Wielders EAL, Dekker RJ, Holt I, Morris GE and Te Riele H. (2011)
Characterization of MSH2 variants by endogenous gene modification in mouse embryonic stem cells.
Human Mutation in press

Aarts M and Te Riele H (2010)
Progress and prospects: oligonucleotide-directed gene modification in mouse embryonic stem cells: a route to therapeutic application.
Gene Ther; December 16: doi:10.1038/gt.2010.161.

Van Harn T, Foijer F, van Vugt M, Banerjee R, Yang F, Oostra A, Joenje H, Te Riele H (2010)
Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling.
Genes Dev 24, 1377-138.

Aarts M, Te Riele H (2010b)
Subtle gene modification in mouse ES cells: evidence for incorporation of unmodified oligonucleotides without induction of DNA damage.
Nucleic Acids Res. [Epub ahead of print]

Aarts M, Te Riele H (2010a)
Parameters of oligonucleotide-mediated gene modification in mouse ES cells.
J Cell Mol Med 14-6b, 1657-1667.

Bakker ST, van de Vrugt HJ, Rooimans MA, Oostra AB, Steltenpool J, Delzenne-Goette E, van der Wal A, van der Valk M, Joenje H, Te Riele H, de Winter JP (2009)
Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.
Hum Mol Genet 18, 3484-95.

Wielders E, Dekker M, Te Riele H (2009)
Generation of double-knockout embryonic stem cells.
Methods Mol Biol 530, 205-18.

Aarts M, Dekker M, Dekker R, de Vries S, van der Wal A, Wielders E, Te Riele H (2009)
Gene modification in embryonic stem cells by single-stranded DNA oligonucleotides.
Methods Mol Biol 530, 79-99.

Te Riele H (2009)
Recreating stem cells: a novel entrance to the fountain of youth - Preview.
Cell Stem Cell 4, 279-80.

Vormer TL, Foijer F, Wielders CLC, Te Riele H (2008)
Anchorage-independent growth of pocket-protein-deficient murine fibroblasts requires bypass of G2 arrest and can be accomplished by expression of TBX2.
Mol Cell Biol 28, 7263-73.

Foijer F, Simonis M, Van Vliet M, Kerkhoven R, Sorger PK, Te Riele H (2008)
Oncogenic pathways impinging on the G2 restriction point.
Oncogene 27, 1142-54.

Te Riele H (2007)
Retinoblastoma teaches a new lesson - Preview.
Cell, 131, 227-9.

Foijer F, Delzenne-Goette E, Dekker M, Te Riele H (2007)
In vivo significance of the G2 restriction point.
Cancer Res 67, 9244-7.

Aarts M, Dekker M, De Vries S, Van der Wal A, Te Riele H (2006)
Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells.
Nucleic Acids Res. 34, e147.

Foijer F and Te Riele H (2006)
Restriction beyond the restriction point: mitogen requirement for G2 passage.
Cell Division May18:1-8.

Foijer F and Te Riele H (2006)
Check, double check: The G2 barrier to cancer.
Cell Cycle 5, 831-836.

Dekker M, Brouwers C, Aarts M, Van der Torre J, De Vries S, Van de Vrugt H, Te Riele H (2006)
Effective oligonucleotide-mediated gene disruption in ES cells lacking the mismatch repair protein MSH3.
Gene Ther 13, 686-694.

Foijer F, Wolthuis RMF, Doodeman D, Medema RM, Te Riele H (2005)
Mitogen requirement for cell cycle progression in the absence of pocket protein activity.
Cancer Cell 8, 455-66.

Dannenberg, J.-H. and Te Riele, H.J.P. (2006)
The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis.
In: Kaldis, P. (ed.) Cell Cycle Regulation. Results and Problems in Cell Differentiation, vol. 42. Springer Berlin, Heidelberg, New York, pp 183-226.

Dannenberg, J-H, Schuijff L, Dekker M, Van der Valk M and Te Riele H (2004)
Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.
Genes Dev 18, 2952-2962.

Claij N, and Te Riele H (2003)
Msh2 deficiency does not contribute to cisplatin resistance in mouse embryonic stem cells.
Oncogene 23, 260-266.

Claij N, Van der Wal A, Dekker M, Jansen L and Te Riele H (2003)
DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis.
Cancer Res 63, 2062-2066.

Dekker M, Brouwers C, Te Riele H (2003)
Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oliogonucleotides.
Nucleic Acids Res 31, e27.

Vooijs M, Te Riele H, Van der Valk M, Berns A (2002)
Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells.
Oncogene 21, 4635-4645.

Claij N, and Te Riele, H (2002)
Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level.
Oncogene 21, 2873-2879.

Van den Broek W, Nelen MR, Wansink DG, Coerwinkel MM, Te Riele H, Groenen PJTA, and Wieringa B. (2002)
Somatic expansion behaviour of the (CTG)n-repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.
Human Mol Genet 11,191-198

Peeper DS, Dannenberg J-H, Douma S, Te Riele H, and Bernards R. (2001)
Escape from premature senescence is not sufficient for oncogenic transformation by Ras.
Nature Cell Biol 3, 198-203.

Dannenberg J-H, Van Rossum A, Schuijff L, and Te Riele H. (2000)
Ablation of the retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions.
Genes Dev 14, 3051-3064.

De Wind, N., Dekker, M., Claij, N., Jansen, L., Van Klink, Y., Radman, M., Riggins, G., Van der Valk, M., Van 't Wout, K., and Te Riele, H. (1999)
HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.
Nat. Genet. 23, 359-362.

Jansen, L., Claij, N., Dekker, M., Van Klink, Y., Van der Valk, M., Van 't Wout, K., and Te Riele, H. (2000)
Acceleration of lymphomagenesis in mismatch-repair deficient mice by exposure to genotoxic agents.
Toxicology Letters, 112-113, 245-250.

De Vries, S.S., Baart, E.B., Dekker, M., Siezen, A., De Rooij, D.G., De Boer, P., and Te Riele, H. (1999)
Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis.
Genes & Dev. 13, 523-531

Claij, N. and Te Riele, H. (1999)
Microsatellite instability in human cancer: a prognostic marker for chemotherapy?
Exp. Cell Res. 246, 1-10.

DeWeese, T.L., Shipman, J.M., Larrier, N.A., Buckley, N.M., Kidd, L.R., Groopman, J.D., Cutler, R.G., Te Riele, H., and Nelson, W.G. (1998)
Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.
Proc. Natl. Acad. Sci. USA 95, 11915-11920.

Robanus Maandag, E., Dekker, M., Van der Valk, M., Carozza, M.-L., Jeanny, J.-C., Dannenberg, J.-H., Berns, A., and Te Riele, H. (1998)
p107 is a suppressor of retinoblastoma development in pRb-deficient mice.
Genes & Dev. 12, 1599-1609.

De Wind, N., Dekker, M., Van Rossum, A., Van der Valk, M., and Te Riele, H. (1998)
Mouse models for hereditary nonpolyposis colorectal cancer.
Cancer Res. 58, 248-255.

De Wind, N., Dekker, M., Berns, A., Radman, M., and Te Riele, H. (1995)
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.
Cell 82, 321-330.

Robanus Maandag, E., van der Valk, M., Vlaar, M., Feltkamp, S., O'Brien, J., van Roon, M., van der Lugt, N., Berns, A. and te Riele, H. (1994)
Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.
EMBO J. 13, 4260-4268.

Clarke, A.R., Robanus Maandag, E., van Roon, M., van der Lugt, N.M.T., van der Valk, M., Hooper, M.L., Berns, A. and te Riele, H. (1992)
Requirement for a functional Rb-1 gene in murine development.
Nature 259, 328-330.

Te Riele, H., Robanus Maandag, E. and Berns, A. (1992)
Highly efficient gene targeting in embryonic stem cells via homologous recombination with isogenic DNA constucts.
Proc. Natl. Acad. Sci. USA 89, 5128-5132.